Silibinin protects GLUTag cells from PA-induced injury via suppressing endoplasmic reticulum stress

Silibinin is a natural flavonoid with anti-diabetic activity. Glucagon-like peptide−1 (GLP−1), an intestinal hormone mainly secreted from L cells, which regulates insulin production and sensitivity, appears to be potential therapeutic strategy for T2DM. The current study aims determine the protective effect of silibinin against palmitic acid (PA)-induced damage in GLUTag cells. results revealed that PA triggered endoplasmic reticulum (ER) stress apoptosis while attenuated PA-induced lipotoxicity. Based on estrogen-like effects role estrogen receptors regulating glycolipid metabolism, involvement cells was further investigated. showed receptor α- β-specific inhibitors reversed inhibitory impact ER stress. Our demonstrated protects injury by decreasing under regulation α β.